Prescott has rushed for more than 100 yards in three of his last four games and faces a Kentucky defense that allows 213.3 yards per game on the ground.
Jerron Seymour, RB-Vanderbilt at Texas A&M
The Commodores may not leave College Station with a win Saturday night, but you can bet that they will lean heavily on Seymour, especially with the Aggies defense allowing over 225 yards per game on the ground.
Jarrod Lawson, RB-San Jose State vs Wyoming
Looking for a sleeper running back this weekend? Keep your eyes on this freshman back as he faces a Wyoming defense that allows 247.6 rushing yards per game.
Tyler Winston, WR-San Jose State vs Wyoming
In the past two games, the freshman receiver has caught 14 passes for 310 yards and two touchdowns opposite Chandler Jones in the Spartans offense.
Kendall Brock, RB-Nevada vs UNLV
Caleb Herring, QB-UNLV at Nevada
Only five teams in the FBS give up more rushing yards per game than the Rebels, who are allowing 251.4 yards on the ground. Interestingly, the Wolfpack rank second-to-last in the FBS in rushing yards allowed at 287.1 yards per game.
Jawon Chisholm, RB-Akron vs Ball State
Chisholm is coming off a three touchdown performance against Miami (OH) last weekend and faces a Ball State defense that is allowing 204.5 yards per game on the ground.
Kenyan Drake, RB-Alabama vs Tennessee
The sophomore running back has topped 100 yards and scored two touchdowns in consecutive games and fantasy owners would be wise to ride him while he is hot.
Travis Wilson, QB-Utah at USC
Wilson’s hand injury was bad enough to keep him out of the second half of last week’s game at Arizona. This week, the USC defense may be a bigger problem than Wilson’s hand injury.
Jared Goff, QB-Cal at Washington
There is a chance that Zach Kline could start at quarterback for the Bears against Washington on Saturday.
Adam Muema, RB-San Diego State vs Fresno State
If the high-powered Bulldogs offense gets off to a fast start and Fresno State jumps to an early lead, Donnel Pumphrey could see most of the snaps in the Aztecs backfield.
Rajion Neal, RB-Tennessee at Alabama
We are going to stay true to our game and bench another running back against the Alabama defense.
Marcus Shaw, RB-South Florida vs Louisville
Shaw should make his return from injury this week, but his fantasy owners may want to wait until the Bulls play at Houston next Thursday before starting the senior running back.
Lyle McCombs, RB-Connecticut at Central Florida
McCombs rushed for 164 yards two weeks ago against South Florida, but in the Huskies five other games, the junior running back has posted a disappointing 214 rushing yards.
Zach Zwinak, RB-Penn State at Ohio State
Zwinak only carried the ball eight times in last week’s 4OT thriller against Michigan and fellow running back Bill Belton is coming on strong.